Inauhzin

Inauhzin is a novel small molecule that reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell) effectively By increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, INZ stabilizes p53,though not directly in vitro. Remarkably, INZ inhibits cell proliferation, induces senescence and tumour-specific apoptosis.