Imatinib Mesylate (CGP-57148B, STI-571)

Alternate Name/Synonyms: CGP-57148B, STI-571

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 220127-57-1

Molecular Formula: C₂₉H₃₁N₇O.CH₄SO₃

Molecular Weight: 589.71

Purity: ≥99% by HPLC

Solubility: DMSO (100 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: RT

Description: An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (ICâ‚…â‚€ = 0.5 nM), phosphorylation of a fusion protein (ICâ‚…â‚€ = 30 nM), and viability of BaF3 cells expressing Rhe-PDGFRα in the absence of IL-3 (ICâ‚…â‚€ = 0.17 nM).

Handling: Protect from air and moisture