IGF2 Antibody

Insulin-like Growth Factors IGF1 and IGF2 share 76% sequence identity and are 50% related to pro-insulin. They are non-glycosylated, single-chain proteins of 70 and 76 amino acids in length respectively. IGF1 functions as an autocrine regulator of growth in various tissues, whereas IGF2 is found in placenta. Defects in IGF1 are the cause of insulin-like growth factor I deficiency defined by growth retardation, sensorineural deafness and mental retardation.