IGF1 Protein, Mouse, Recombinant

IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and
IGF1, is a secreted protein which belongs to the?insulin family. The insulin
family, comprised of insulin, relaxin, insulin-like growth factors I and II
( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor,
represents a group of structurally related polypeptides whose biological
functions have diverged. The IGFs, or somatomedins, constitute a class of
polypeptides that have a key role in pre-adolescent mammalian growth.
IGF-I expression is regulated by GH and mediates postnatal growth, while
IGF-II appears to be induced by placental lactogen during prenatal
development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-
deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.
IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic
(PyMS) cells and is effective at much lower concentrations than insulin, not
only regarding glycogen and DNA synthesis but also with regard to
enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulinlike
growth factor I deficiency (IGF1 deficiency) which is an autosomal
recessive disorder characterized by growth retardation, sensorineural
deafness and mental retardation