IGF-1 ELISA

pIGF-1 ELISAbr /
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pimg alt=For Research Use Only src=http://www.alpco.com/img/ruo.gif align=absMiddle / For Research Use Only/p
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div class=prod_specbFormat:/b/div
div class=prod_spec_infoELISA / EIA/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoserum, plasma/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info50 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info96 wells/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info45 - 1330 ng/ml/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info4.9 ng/ml/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_info2 Hour 30 Min/div
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pbSummary:/b/p
This enzyme linked immunosorbent assay is for the determination of serum Insulin-like growth factor-1 (IGF-1) levels. Insulin-like growth factor-1 (IGF-1), also called Somatomedin-C, is a low molecular weight peptide (7649 da; 70 aa) which promotes cellular mitosis and differentiation in a variety of tissues. The liver is the main source of circulating IGF-1 and its synthesis is regulated by Growth Hormone (GH). Several other tissues produce IGF-1 and these productions are regulated by GH or other modulators.br /
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Contrary to the ultradian rhythm of GH secretion, the IGF-1 secretion pattern presents negligible nychthemeral variations. The majority of circulating IGF-1 is bound to plasma IGF binding proteins (IGFBPs), particularly IGFBP-3. Less than 1% IGF-1 is free. Circulating IGFBP-3 is directly correlated with the rate of GH secretion. br /
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In humans, serum IGF-1 levels are low during fetal and neonatal life, increase gradually during puberty, peaking at Tanner stages 3-4, and show a decline similar to GH with aging. Average IGF-1 plasma levels are slightly higher in females at each age stage than in males. There is a significant correlation between IGF-1 values and plasma sex steroid concentrations. Sex steroids influence IGF-1 levels via an increase in GH secretion. In addition, IGF-1 levels are dependent on both caloric intake and protein content of the diet./div
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