Kits
IgE Total ELISA
Kits
Description
Immunoglobulin E (IgE) is an antibody isotypes, found
only in mammals. Although IgE is typically the least
abundant isotype - blood serum IgE levels in a normal
(non-atopic) individual are ~150ng/mL, compared to
10mg/mL for the IgGs (the isotypes responsible for
most of the classical adaptive immune response) - it
is capable of triggering the most powerful immune
reactions. Most of our knowledge of IgE has come
from an allergy known as type 1 hypersensitivity.
IgE plays an important role in allergy, and in the
immune system’s recognition of cancer.
People who suffer from true IgE-mediated allergies
can have up to 10 times the normal level of IgE in
their blood (as do sufferers of hyper-IgE syndrome).
The IgE molecules (MW 200,000) bind to the surface
of the mast cells and basophilic granulocytes.
Subsequently the binding of allergen to cell-bound IgE
causes these cells to release histamines and other
vasoattive substances. The release of histamines in
the body results initiates what is commonly known as
an allergic reaction.
IgE levels show a slow increase during childhood,
reaching adult levels in the second decade of life. In
general, the total IgE levels increase with the allergies
a person has and the number of times of exposure to
the relevant allergens. Significant elevations may be
seen in the sensitised individuals, but also in cases of
myeloma, pulmonary aspergillosi, and during the
active stages of parasitic infections.
The measurement of immunoglobulin E (IgE) in
serum is widely used in the diagnosis of allergic
reactions and parasitic infections. Before making any
therapeutic determination it is important, however, to
know whether the allergic reaction is IgE mediated or
non-IgE mediated. Measurement of total IgE in serum
sample, along with other supporting diagnostic
information, can help to make that determination.
only in mammals. Although IgE is typically the least
abundant isotype - blood serum IgE levels in a normal
(non-atopic) individual are ~150ng/mL, compared to
10mg/mL for the IgGs (the isotypes responsible for
most of the classical adaptive immune response) - it
is capable of triggering the most powerful immune
reactions. Most of our knowledge of IgE has come
from an allergy known as type 1 hypersensitivity.
IgE plays an important role in allergy, and in the
immune system’s recognition of cancer.
People who suffer from true IgE-mediated allergies
can have up to 10 times the normal level of IgE in
their blood (as do sufferers of hyper-IgE syndrome).
The IgE molecules (MW 200,000) bind to the surface
of the mast cells and basophilic granulocytes.
Subsequently the binding of allergen to cell-bound IgE
causes these cells to release histamines and other
vasoattive substances. The release of histamines in
the body results initiates what is commonly known as
an allergic reaction.
IgE levels show a slow increase during childhood,
reaching adult levels in the second decade of life. In
general, the total IgE levels increase with the allergies
a person has and the number of times of exposure to
the relevant allergens. Significant elevations may be
seen in the sensitised individuals, but also in cases of
myeloma, pulmonary aspergillosi, and during the
active stages of parasitic infections.
The measurement of immunoglobulin E (IgE) in
serum is widely used in the diagnosis of allergic
reactions and parasitic infections. Before making any
therapeutic determination it is important, however, to
know whether the allergic reaction is IgE mediated or
non-IgE mediated. Measurement of total IgE in serum
sample, along with other supporting diagnostic
information, can help to make that determination.