IC87114

Alternate Name/Synonyms: 2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 371242-69-2

Molecular Formula: C₂₂H₁₉N₇O

Molecular Weight: 397.43

Purity: ≥95% by HPLC

Solubility: DMSO

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110δ (ICâ‚…â‚€ = 60 nM). Inhibits p110α and p110β only at higher concentrations (>1 µM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100 µM.

Handling: Protect from air and light