μ-Conotoxin GIIIB
- 貨號 Cat. No.
- C-270
- 規格 Size
- 0.1 mg 5x0.1mg
Description
m-Conotoxin GIIIB
A Selective Blocker of Skeletal Muscle Nav1.4 Channels
| Product#: | C-270 |
| Sizes: |
| 0.1 mg |
| 5 x 0.1 mg |
m-Conotoxin GIIIB was originally isolated from the marine snail Conus geographus and this is a synthetic verssion of the peptide. m-Conotoxin GIIIB selectively blocks Nav1.4 channels which are expressed predominantly in muscle.1,2 It is a potent blocker and 600 nM completely blocked Nav1.4 related currents in rat skeletal muscle.3
| M.W.: | 2640 |
| Purity: | >99% |
| Bioassay: |
| Inhibition of the skeletal muscle specific Nav1.4 channel by m-Conotoxin GIIIB in Xenopus oocytes. |
 |
Legend: 100 nM m-Conotoxin GIIIB strongly inhibits Nav1.4 channel currents expressed in Xenopus oocytes. Holding potential was -100 mV and test pulses of 25 ms to -20 mV were delivered every 5 seconds. Left: Time course of current inhibition by toxin and recovery. The bar represents period of toxin perfusion. Right: Superimposed traces of Nav1.4 current before (black) and during (orange) application of toxin. |
| References: |
1. | Cruz, L. J. et al. (1985) J. Biol. Chem. 260, 9280. |
2. | Li, R. A. et al. (2003) J. Biol. Chem. 278, 8717. |
3. | Filatov, G. N. and Rich, M. M. (2004) J. Physiol. 559, 813. |
4. | Robitaille, R. and Charlton, M.P. (1992) J. Neuroscience 12, 297. |