- 貨號 Cat. No.
- D-370
- 規格 Size
- 70 μg 5x70 μg
Description
g-Dendrotoxin
A Potent and Specific Blocker of Kv1.1 Channels
Sequence: |
unidentified completely. |
Bioassay: |
g-Dendrotoxin was potent in blocking cloned Kv1.1 channels (80?%, n=4), but blocked only a relatively small fraction (21?%, n=4) of cloned Kv1.2 channels, both expressed in Xenopus oocytes.
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Kv1.1 (left, in 2mM K+) and Kv1.2 (right, in 5mM K+) channel currents, elicited by 200 ms depolarization from holding potential of -100 mV to +20 mV, before and during application of 100 nM g-Dendrotoxin.
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1.
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Harvey, A.L. and Anderson, A.J. (1985) Pharmacol. Ther. 31, 33.
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2.
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Benishin, C.G. et al. (1988) Mol. Pharmacol. 34, 152.
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g-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom, by modification of the procedures of Harvey1 and Benishin2 and purified to homogeneity.
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