β-Pompilidotoxin
- 貨號 Cat. No.
- P-180
- 規格 Size
- 1 mg 5x1mg
Description
b-Pompilidotoxin (b-PMTX)
Enhancer of NaV Currents (Slows inactivation)
| Product#: | P-180 |
| Sizes: |
| 1 mg |
| 5 x 1 mg |
-PMTX is a homologous peptide to a-PMTX (position 12 is Arginine instead of Lysine). b-PMTX induces repetitive action potentials and facilitates both excitatory and inhibitory synaptic transmission.
| M.W.: | 1559 |
| Sequence: |
RIKIG LFDQL SRL-NH2 |
| Purity: | >98% |
| Bioassay: |
| Enhancement of native NaV currents in ND7 cells by b-Pompilidotoxin. |
 |
| Legend: The effect on inward currents of bath application of 100mM of b-Pompilidotoxin (cyan trace) to wild type ND7 cells. NaV current were elicited every 15 seconds from holding potential of -100 mV, by a 20 ms test pulse to -10 mV. |
| References: |
1. | Sahara, Y. et al. (2000) Eur. J. of Neurosci. 12, 1961. |
2. | Konno, K. et al. (2000) Neurosci. Lett. 285, 29. |
3. | Konno, K. et al. (1998) Biochem and Biophys.Res. Commun. 250, 612. |
b-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide.
b
Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 b-PMTX is five times more potent than a-PMTX.1,2