α-Pompilidotoxin
- 貨號 Cat. No.
- P-170
- 規格 Size
- 1 mg 5x1mg
Description
a-Pompilidotoxin (a-PMTX)
Enhancer of Nav Currents (Slows Inactivation)
| Product#: | P-170 |
| Sizes: |
| 1 mg |
| 5 x 1 mg |
| M.W.: | 1529 |
| Sequence: |
RIKIG LFDQL SKL-NH2 |
| Purity: | >98% |
| Bioassay: |
| Enhancement of native NaV currents in ND7 cells by a-Pompilidotoxin. |
 |
| Legend: The effect on inward currents of bath application of 100mM of a-Pompilidotoxin (cyan trace) to wild type ND7 cells. NaV current were elicited every 15 seconds from holding potential of -100 mV, by a 20 ms test pulse to -10 mV. |
| References: |
1. | Sahara, Y. et al. (2000) Eur. J. of Neurosci. 12, 1961. |
2. | Konno, K. et al. (2000) Neurosci. Lett. 285, 29. |
3. | Konno, K. et al. (1998) Biochem and Biophys.Res. Commun. 250, 612. |
4. | Harsch, A. et al. (1998) Neurosci. Lett. 252, 49. |
a-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. a-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.
Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 Effective at concentrations of 10 nM in cultured rat cortical neurons.4