Human VSIG4 Protein, His Tag

Source : 

Human VSIG4, His Tag (VS4-H5226) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 283 (Accession # AAH10525).

 

Molecule : VSIG4

 

Synonyms : VSIG4,CRIg,Z39IG

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH10525

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 30.1 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.1 kDa. The protein migrates as 35-47 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

V-set and immunoglobulin domain-containing protein 4 (VSIG4) is also known as Protein Z39Ig, is a type I transmembrane glycoprotein. VSIG4 is a B7 family-related protein and an Ig superfamily member. VSIG4 contains two Ig-like (immunoglobulin-like) domains. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production.

 

References :

(1) Vogt L., et al., 2006, J. Clin. Invest. 116:2817-2826.
(2) Wiesmann C., et al., 2006, Nature 444:217-220.