Human VSIG3 Protein, Fc Tag

Source : 

Human VSIG3, Fc Tag (VS3-H5258) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 241 (Accession # Q5DX21-1).

 

Molecule : VSIG3

 

Synonyms : VSIG3,IgSF11,CXADRL1,Bt-IgSF,CT119

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001015887.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 49.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.

 

References :

(1) Jang S, et al. 2016. Nat Neurosci. 19(1):84-93.
(2) Watanabe T, et al. 2005. Cancer Science. 96(8):498-506.
(3) Wang J, et al. 2019. Immunology. 156(1):74-81.
(4) Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.