Human VEGF R3 / FLT4 Protein, Fc Tag

Source : 

Human VEGF R3, Fc Tag (FL4-H5251) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 776 (Accession # NP_002011.2).

 

Molecule : VEGF R3

 

Synonyms : Flt-4,FLT4,LMPH1A,PCLFLT41,VEGFR3,VEGFR-3,FLT-4,FLT-41,FLT41,PCL

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_002011.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 111.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 111.2 kDa. As a result of glycosylation, the protein migrates as 140-160 kDa under reducing (R) condition, and 280-320 kDa under non-reducing (NR) condition (SD

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

 

References :

(1)Stuttfeld E., et al., 2009, IUBMB Life, 61 (9): 915-922.
(2)Zygmunt T., et al., 2011, Dev Cell, 21 (2): 301-314.
(3)Herzog, B., et al., 2011, Molecular Biology of the Cell, 22 (15): 2766-2776.