Human Vasorin / VASN Protein, His Tag

Source : 

Human Vasorin, His Tag (VAN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Cys 24 - Pro 575 (Accession # AAH68575).

 

Molecule : Vasorin

 

Synonyms : VASN,SLITL2,Vasorin

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH68575

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 61.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 61.6 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Vasorin (VASN),a single-pass type I membrane protein, is also known as protein slit-like 2 and SLITL2, which contains one EGF-like domain, ten LRR (leucine-rich) repeats, one LRRCT domain and one LRRNT domain. VASN is expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. VASN can interact selectively and non-covalently with TGF-beta, transform growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. In general, VASN may act as an inhibitor of TGF-beta signaling.

 

References :

(1) Ikeda Y., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737.
(2) Chen R., et al., 2009, J. Proteome Res. 8:651-661.