Human uPAR / PLAUR Protein, His Tag

Source : 

Human uPAR, His Tag (UPR-H5226) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # AAH02788).

 

Molecule : uPAR

 

Synonyms : uPAR,PLAUR,CD87,MO3

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH02788

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 32.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Urokinase plasminogen activator surface receptor (U-PAR) is also known as PLAUR, Monocyte activation antigen Mo3, CD antigen CD87. PLAUR contains three UPAR/Ly6 domains. U-PAR is expressed in neurons of the rolandic area of the brain (at protein level) and is also expressed in the brain. PLAUR / CD87 interacts with MRC2, SRPX2 and SORL1. PLAUR / UPAR acts as a receptor for urokinase plasminogen activator and plays a role in localizing and promoting plasmin formation. U-PAR mediates the proteolysis-independent signal transduction activation effects of U-PA.

 

References :

(1) Behrendt N., et al., 2000, J. Biol. Chem. 275:1993-2002.
(2) Royer-Zemmour B., et al., 2008, Hum. Mol. Genet. 17:3617-3630.
(3) Huai Q., et al., 2006, Science 311:656-659.