Human TYRO3 / Dtk Protein, Fc Tag

Source : 

Human TYRO3, Fc Tag (TY3-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 41 - Ser 428 (Accession # AAH51756.1 (Q261H)).

 

Molecule : TYRO3

 

Synonyms : TYRO3,BYK,DTK,RSE,SKY,TIF

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH51756.1 (Q261H)

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 68.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 86-106 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.

 

References :

(1) Shimojima M., et al., 2006, J. Virol. 80:10109-10116.
(2) Cosemans J.M., et al., 2010, J. Thromb. Haemost. 8:1797-1808.
(3) Heiring C., et al., 2004, J. Biol. Chem. 279:6952-6958.