Human Tyk2 Protein, His Tag (MALS verified)

Source : 

Human Tyk2, His Tag (TY2-H5549) is expressed from Baculovirus-Insect cells. It contains AA Asn 575 - Leu 869 (Accession # P29597-1).

 

Molecule : Tyk2

 

Synonyms : Tyk2,tyrosine kinase 2

 

Format : Liquid

 

Category : Enzymes

 

Accession : N/A

 

Storage : -70℃

 

Shipping condition : Liquid,-70℃Dry ice

 

Molecular Weight : 35.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 35.0 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM HEPES, 500 mM NaCl, 2 mM TCEP, pH7.5

 

Description :

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

 

References :

(1) Colamonici O, et al. Mol Cell Biol. 1994. 14(12):8133-42.
(2) Velazquez L, et al. Cell. 1992. 70(2):313-22.