Human TWEAK R / TNFRSF12A Protein, Fc Tag

Source : 

Human TWEAK R, Fc Tag (TNA-H526a) is expressed from human 293 cells (HEK293). It contains AA Glu 28 - Trp 79 (Accession # AAH02718).

 

Molecule : TWEAK R

 

Synonyms : TNFRSF12A,FGF-inducible 14,FN14,TweakR,CD266

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH02718

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 32.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 32.5 kDa. As a result of glycosylation, the protein migrates as 32-45 kDa under reducing (R) condition, and 55-80 kDa under non-reducing (NR) condition (SDS-PAG

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14 (FN14 or FGF-inducible 14), Tweak-receptor, CD antigen CD266. TNFRSF12A contains one TNFR-Cys repeat. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A is receptor for TNFSF12/TWEAK, and is weak inducer of apoptosis in some cell types. TNFRSF12A / FN14 promotes angiogenesis and the proliferation of endothelial cells.

 

References :

(1) Wiley S.R., et al., 2001, Immunity 15:837-846.
(2) He F., et al., 2009, Protein Sci. 18:650-656.