Human TSLP R Protein, Fc Tag

Source : 

Human TSLP R, Fc Tag (TSR-H525a) is expressed from human 293 cells (HEK293). It contains AA Gly 25 - Lys 231 (Accession # Q9HC73-1).

 

Molecule : TSLP R

 

Synonyms : TSLP R,CRLF2,IL-XR,ILXR,p2RY8/CRLF2 fusion,TSLP receptor,TSLPR,CRL2,CRLF2Y,Cytokine receptor-like 2

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_071431.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 50.4 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 62-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Receptor for thymic stromal lymphopoietin (TSLP). CRLF2 / TSLPR is a member of the type I cytokine receptor family. Together with the interleukin 7 receptor (IL7R) and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system.

 

References :

(1) Lucia Pattarini, et al., 2017, J Exp Med.214(5): 1529–1546.
(2) Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
(3) Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.