Human TROP-2 / TACSTD2 Protein, His Tag

Source : 

Human TROP-2, His Tag (TR2-H5223) is expressed from human 293 cells (HEK293). It contains AA His 27 - Thr 274 (Accession # P09758-1).

 

Molecule : TROP-2

 

Synonyms : TACSTD2,GA733-1,M1S1,TROP2

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_002344.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 29.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.8 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

 

References :

(1) Simms A., et al., 2016, Diagn. Cytopathol. 44(1):26-31.
(2) Fornaro M., et al., 1995, Int. J. Cancer. 62(5):610-618.