Human TrkA / NTRK1 (33-417) Protein, Mouse IgG2a Fc Tag

Source : 

Human TrkA (33-417), Mouse IgG2a Fc Tag (TRA-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 33 - Gly 417 (Accession # P04629-2).

 

Molecule : TrkA

 

Synonyms : TrkA,NTRK1,MTC,TRK,TRKA,Trk-A

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_001012331.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 68.2 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 80-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

 

References :

(1) Hempstead BL, et al. 1991. Nature. 350(6320):678-83.
(2) Klein R, et al. 1991. Cell. 65:189-197.
(3) Jing S, et al. 1992. Neuron. 9(6):1067-79.