Human Transthyretin / Prealbumin Protein, His Tag

Source : 

Human Transthyretin, His Tag (TTR-H5223) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Glu 147 (Accession # NP_000362).

 

Molecule : Transthyretin

 

Synonyms : Transthyretin,TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_000362

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 14.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.9 kDa. The protein migrates as 19 kDa and 37 kDa under reducing (R) condition (SDS-PAGE) due to the monomer and dimer respectively.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Transthyretin (TTR) is also known as Prealbumin, ATTR, TBPA, PALB, which belongs to the transthyretin family. Transthyretin / TTR is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. In cerebrospinal fluid TTR is the primary carrier of T4. TTR also acts as a carrier of retinol (vitamin A) through its association with retinol-binding protein (RBP) in the blood and the CSF. Less than 1% of TTR's T4 binding sites are occupied in blood. TTR misfolding and aggregation is known to be associated with the amyloid diseases.

 

References :

(1) Getz R.K., et al., 1999, Exp. Eye Res. 68:629-636.
(2) Herbert J., et al., 1986, Neurology 36:900-911.
(3) Mita S., et al., 1984, Biochem. Biophys. Res. Commun. 124:558-564.