Human TGF-beta RII / TGFBR2 Protein, Fc Tag

Source : 

Human TGFBR2, Fc Tag (TG2-H5252) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Asp 159 (Accession # NP_003233).

 

Molecule : TGF-beta RII

 

Synonyms : TGFBR2,TGFR2,TbetaR-II,TGFβR2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_003233

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

 

References :

(1) Wieser R., et al., 1995, EMBO J. 14:2199-2208.
(2) Deep S., et al., 2003, Biochemistry 42:10126-10139.
(3) Groppe J., et al., 2008, Mol. Cell 29:157-168.