Human TFPI-2 Protein, His Tag

Source : 

Human TFPI-2, His Tag (TF2-H5227) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Lys 213 (Accession # NP_006519.1).

 

Molecule : TFPI-2

 

Synonyms : TFPI2,PP5,REF1

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_006519.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 22.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 26-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tissue Factor Pathway Inhibitor 2 (TFPI­2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF­1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI­2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

 

References :

(1) Rao C.N., et al., 1995, Arch. Biochem. Biophys. 317:311-314.
(2) Tanaka Y., et al., 2004, Invest. Ophthalmol. Vis. Sci. 45:245.  
(3) Rollin J., et al., 2005, Br, J. Cancer 92:775.