Human TDGF1 / Cripto Protein, Fc Tag

Source : 

Human TDGF1, Fc Tag (CRO-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 31 - Thr 172 (Accession # P13385-1).

 

Molecule : TDGF1

 

Synonyms : TDGF1,CRGF,CRIPTO

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_003203

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 44-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Teratocarcinoma-derived growth factor 1 (TDGF1) is also known as Cripto-1 growth factor (CRGF), Epidermal growth factor-like cripto protein CR1, CRIPTO, is a cell membrane which contains one EGF-like domain. TDGF1 is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 interacts with the activin type-1 receptor ACVR1B. TDGF1 could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

 

References :

(1) Bianco C., et al., 2002, Mol. Cell. Biol. 22:2586-2597.
(2) Foley S.F., et al., 2003, Eur. J. Biochem. 270:3610-3618.
(3) Sun C., et al., 2008, Biochem. Biophys. Res. Commun. 377:215-220.