Human Tau-441 / 2N4R Protein, His Tag

Source : 

Human Tau-441, His Tag (TAU-H51H3) is expressed from E.coli cells. It contains AA Met 1 - Leu 441 (Accession # P10636-8).

 

Molecule : Tau-441

 

Synonyms : DDPAC,FTDP-17,MAPT,MSTD,MTBT1,Tau,PHF-tau,TAU

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_005901.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 47.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.9 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, 1 mM TCEP, 1 mM EDTA, pH7.5

 

Description :

Tau is a microtubule-associated protein, which encodes by the MAPT gene that located on chromosome 17q21. Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies. Tau-441 is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-441 is a potential therapeutic target for pathogenesis.

 

References :

(1) Yoshida H, et al. 2012. J. Neurochem. 120:165-176.
(2) Alonso A., et al. 2001.Proc. Natl. Acad. Sci. U.S.A.98 (12): 6923–8