Human Syndecan-1 Protein, His Tag

Source : 

Human Syndecan-1, His Tag (SD1-H5228) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Gly 254 (Accession # AAH08765).

 

Molecule : Syndecan-1

 

Synonyms : SDC1,Syndecan-1,CD138,SYND1,SDC

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH08765

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 24.7 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.7 kDa. The protein migrates as 44 kDa and 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

 

References :

(1) Bhatt A.S., et al., 2005, Oncogene 24:5333-5343.
(2) Subramanian S.V., et al., 1997, J. Biol. Chem. 272:14713-14720.
(3) Rawstron AC., 2006, Curr Protoc Cytom. Chapter 6: Unit6.23.