Human SOD2 / Mn-SOD Protein, His Tag

Source : 

Human SOD2, His Tag (SO2-H5126) is expressed from E.coli cells. It contains AA Lys 25 - Lys 222 (Accession # AAH12423).

 

Molecule : SOD2

 

Synonyms : SOD2,IPOB,MNSOD

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH12423

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 23.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.2 kDa. The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Superoxide dismutase [Mn], mitochondrial (SOD2),a member of the iron/manganese superoxide dismutase family, can form a homotetramer and bind one manganese ion per subunit. The expression of SOD2 is regulated by KRIT1. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), sporadic motor neuron disease, and cancer. Furthermore, Mn-SOD (SOD2) activity is essential to achieve optimal training-induced protection against both ischemia/reperfusion(IR)-induced cardiac arrhythmias and infarction.

 

References :

(1) Choudhary C., et al., 2009, Science 325:834-840.
(2) Borgstahl G.E.O., et al., 1996, Biochemistry 35:4287-4297.
(3) Hearn A.S., et al., 2001, Biochemistry 40:12051-12058.