Human SOD1 / Cu-Zn SOD Protein, His Tag

Source : 

Human SOD1, His Tag (SO1-H5148) is expressed from E.coli cells. It contains AA Ala 2 - Gln 154 (Accession # P60052-1).

 

Molecule : SOD1

 

Synonyms : SOD1,Superoxide dismutase 1,hSod1

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH01034

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 16.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 16.8 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

Superoxide dismutase [Cu-Zn] (SOD1) is also known as superoxide dismutase 1 (hSod1), an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 can bind copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Furthermore, the mutations of SOD1 gene can result in a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord.

 

References :

(1) Kostrzewa M., et al.,1996, Hum. Genet. 98:48-50.
(2) Banci L., et al., 2013, ChemBioChem 14:1839-1844.
(3) Rosen D.R., et al., 1993, Nature 362:59-62.