Human SLAMF7 / CRACC / CD319 Protein, His Tag

Source : 

Human SLAMF7, His Tag (SL7-H5225) is expressed from human 293 cells (HEK293). It contains AA Ser 23 - Met 226 (Accession # AAH27867).

 

Molecule : SLAMF7

 

Synonyms : SLAMF7,CD319,CS1,CRACC,19A,FOAP-12

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH27867

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 23.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.2 kDa. The protein migrates as 34-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

 

References :

(1) Bouchon A., et al., 2001, J. Immunol. 167:5517-5521.
(2) Murphy J.J., et al., 2002, Biochem. J. 361:431-436.