Human SIRP gamma / CD172g Protein, Fc Tag

Source : 

Human SIRP gamma, Fc Tag (SIG-H5253) is expressed from human 293 cells (HEK293). It contains AA Glu 29 - Ser 364 (Accession # AAH64532).

 

Molecule : SIRP gamma

 

Synonyms : SIRPG,CD172g,SIRPB2,SIRP-gamma,SIRP-b2,SIRP-beta-2,Cripto-1

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAH64532

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 63.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 68-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Signal-regulatory protein gamma (SIRPG or SIRP-gamma) is also known as CD172 antigen-like family member B (CD172g), Signal-regulatory protein beta-2 (SIRPB2), is a single-pass type I membrane protein. SIRPG is expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. SIRPG interacts with CD47. On binding with CD47, CD172g mediates cell-cell adhesion.

 

References :

(1) Ichigotani Y., et al., 2000, J. Hum. Genet. 45:378-382.
(2) Piccio L., et al., 2005, Blood 105:2421-2427.