Human SIRP beta / CD172b Protein, Fc Tag

Source : 

Human SIRP beta, Fc Tag (SIA-H5257) is expressed from human 293 cells (HEK293). It contains AA Glu 30 - Leu 371 (Accession # O00241-1).

 

Molecule : SIRP beta

 

Synonyms : CD172b antigen,CD172b,DKFZp686A05192,FLJ26614,SIRP beta 1,SIRPB1,SIRP-BETA-1,9930027N05Rik,SIRP-beta

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_006056.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 63.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPβ1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPβ1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPβ1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.

 

References :

(1) Gaikwad S., et al. 2009, Am J Pathol., 175(6), 2528-39.
(2) Dietrich J., et al. 2000, J Immunol., 164(1), 9-12.
(3) Tomasello E., et al. 2000, Eur J Immunol., 30(8), 2147-56.