Human Siglec-9 Protein, Fc Tag

Source : 

Human Siglec-9, Fc Tag (SI9-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Gly 348 (Accession # Q9Y336-1).

 

Molecule : Siglec-9

 

Synonyms : Siglec-9,SIGLEC9,CDw329,CD329

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_055256.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 62.5 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 62.5 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

 

References :

(1) Foussias G, et al. Genomics. 2000. 67(2):171-8.
(2) Liu YC, et al. Front Immunol. 2017. 8:1601.
(3) Angata T, et al. J Biol Chem. 2000. 275(29):22127-35.