Human Siglec-6 / CD327 Protein, Fc Tag

Source : 

Human Siglec-6, Fc Tag (SI6-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 16 - Val 320 (Accession # AAH35359).

 

Molecule : Siglec-6

 

Synonyms : SIGLEC6,CD327,CD33L,CD33L1,OBBP1,OB-BP1,CDw327

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH35359

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 60.3 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.3 kDa. As a result of glycosylation, the protein migrates as 80-100 kDa under reducing (R) condition, and 130-150 kDa and 250-300 kDa under non-reducing (NR

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327, CD33 antigen-like 1 (CD33L or CD33L1), Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family, which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIGLEC6 mediates sialic-acid dependent binding to cells. SIGLEC6 binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

 

References :

(1) Takei Y., et al., 1997, Cytogenet. Cell Genet. 78:295-300.
(2) Patel N., et al., 1999, J. Biol. Chem. 274:22729-22738.