Human Siglec-5 / CD170 Protein, Fc Tag

Source : 

Human Siglec-5, Fc Tag (SI5-H5250) is expressed from human 293 cells (HEK293). It contains AA Glu 17 - Thr 434 (Accession # AAH29896).

 

Molecule : Siglec-5

 

Synonyms : SIGLEC5,OB-BP2,CD170,CD33L2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH29896

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 73.0 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.0 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Sialic acid-binding Ig-like lectin 5 (SIGLEC5) is also known as CD33 antigen-like 2 (CD33L2), Obesity-binding protein 2 (OB-BP2), CD antigen CD170, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 / CD170 is expressed by monocytic / myeloid lineage cells. SIGLEC-5 / CD33-L2 binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

 

References :

(1) Cornish A.L., et al., 1998, Blood 92:2123-2132.
(2) Patel N., et al., 1999, J. Biol. Chem. 274:22729-22738.
(3) Zhuravleva M.A., et al., 2008, J. Mol. Biol. 375:437-447.