Human Siglec-15 / CD33L3 Protein, His Tag

Source : 

Human Siglec-15, His Tag (SG5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1).

 

Molecule : Siglec-15

 

Synonyms : CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_998767.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 28.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 25 mM MES, 150 mM NaCl, pH5.5

 

Description :

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

 

References :

(1) Angata T, et al. 2007. Glycobiology. 178(8):838-846.
(2) Yusuke K, et al. 2015. Bone. 17:217-226.
(3) Hiruma Y. et al. 2011. Biochem Biophys Res Commun. 409(3):424-9.