Human Serpin F1 / PEDF Protein, His Tag

Source : 

Human Serpin F1, His Tag (SE1-H5221) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Pro 418 (Accession # NP_002606).

 

Molecule : Serpin F1

 

Synonyms : SERPINF1,Serpin F1,PEDF,PIG35,EPC-1

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : NP_002606

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 45.2 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.

 

References :

(1) Duh EJ., et al., 2002, Invest Ophthalmol Vis Sci 43 (3): 821–9.
(2) Amaral J., et al., 2010, Invest Ophthalmol Vis Sci 51 (3): 1318–26.
(3) Chen L., et al., 2006, Biochem. Biophys. Res. Commun. 348 (4): 1288–95.