Human Serpin E2 / PN1 Protein, His Tag

Source : 

Human Serpin E2, His Tag (SE2-H5225) is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Pro 397 (Accession # P07093-2).

 

Molecule : Serpin E2

 

Synonyms : SERPINE2,Glia-derived nexin,GDN,Peptidase inhibitor 7,PI-7,Protease nexin 1,PN-1,Serpin E2,SerpinE2,PI7

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : N/A

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 42.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.8 kDa. The protein migrates as 48-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 20 mM Sodium Acetate, 100 mM NaCl, pH6.5

 

Description :

SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.

 

References :

(1) Gloor S.M., et al., 1986, Cell 47:687-693.
(2) Scott R.W., et al., 1985, J. Biol. Chem. 260:7029-7034.