Human Serpin A3 Protein, His Tag

Source : 

Human Serpin A3, His Tag (SE3-H5221) is expressed from human 293 cells (HEK293). It contains AA His 24 - Ala 423 (Accession # AAH03559).

 

Molecule : Serpin A3

 

Synonyms : SERPINA3,ACT,AACT,GIG24,GIG25

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH03559

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 46.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 46.6 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Serpin A3 is also known as Alpha-1-antichymotrypsin (ACT or AACT), Cell growth-inhibiting gene 24/25 protein, which belongs to the serpin family. Serpin A3 can bind DNA. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

 

References :

(1) Rubin H., et al., 1990, J. Biol. Chem. 265:1199-1207.
(2) Kroczynska B., et al., 2004, J. Biol. Chem. 279:11432-11443.
(3) Liu T., et al., 2005, J. Proteome Res. 4:2070-2080.