Human SCARB1 / SR-B1 Protein, Fc Tag

Source : 

Human SCARB1, Fc Tag (SC1-H5258) is expressed from human 293 cells (HEK293). It contains AA Pro 33 - Tyr 443 (Accession # NP_005496.4).

 

Molecule : SCARB1

 

Synonyms : SCARB1,CD36L1,SRB1,CLA-1,SR-BI,HDLQTL6

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005496.4

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 72.7 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 72.7 kDa. As a result of glycosylation, the protein migrates as 110-115 kDa under reducing (R) condition, and 220-230 kDa under non-reducing (NR) condition (SDS

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.

 

References :

(1) Acton S., et al., 1996, Science 271 (5248): 518–20.
(2) Duggan AE., et al., 2002, J. Exp. Zool. 292 (5): 430–4.
(3) Kapadia SB., et al., 2007, J. Virol. 81 (1): 374–83.
(4) Scarselli E., et al., 2002, EMBO J. 21:5017-5025.