Human S100A8 Protein, Tag Free

Source : 

Human S100A8, Tag Free (S18-H5112) is expressed from E.coli cells. It contains AA Met 1 - Glu 93 (Accession # AAH05928).

 

Molecule : S100A8

 

Synonyms : S100A8,60B8AG,CAGA,CFAG,CGLA,CP-10,MRP8,NIF,P8

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH05928

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 10.8 kDa

 

Characteristics :

This protein carries no "tag". The protein has a calculated MW of 10.8 kDa. The protein migrates as 12 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

S100 calcium binding protein A8 (S100-A8) is also kown as Cystic fibrosis antigen, Migration inhibitory factor-related protein 8 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF and P8, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are known to be overexpressed in certain species of carcinomas. S100A8 may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. S100A8 plays an important role in differentiation of thyroid carcinoma possibly by forming a complex with S100A9. S100A8 and S100A9 may also play a key role in inflammation-associated cancer.

 

References :

(1) Schäfer BW, et al., 1996, Trends Biochem. Sci. 21 (4): 134–40.
(2) YASUHIRO ITO, et al., 2009, Anticancer Research October, 29 (10 ):4157-4161.