Human S100A14 Protein, His Tag

Source : 

Human S100A14, His Tag (S14-H5121) is expressed from E.coli cells. It contains AA Met 1 - His 104 (Accession # Q9HCY8-1).

 

Molecule : S100A14

 

Synonyms : S100A14,S114,S100A15

 

Format : Powder

 

Category : Other Recombinant Proteins

 

Accession : AAH05019

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 12.5 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.5 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH8.0

 

Description :

Protein S100-A14 (S100A14) is also known as S100 calcium-binding protein A14 (S114),which belongs to the S-100 family, containing one EF-hand domain.S100A14 is a homodimer can interact with AGER. S100A14 can modulate P53/TP53 protein levels, and play a role in the regulation of cell survival and apoptosis at different concentrations via receptor for advanced glycation end products (RAGE).S100A14 also plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53.

 

References :

(1) Jin Q., et al., 2011, PLoS ONE 6:E19375-E19375.
(2) Chen H., et al., 2012, J. Biol. Chem. 287:17109-17119.
(3) Sapkota D., et al., 2012, Oral Oncol. 48:219-225.