Human PVRIG Protein, Fc Tag

Source : 

Human PVRIG, Fc Tag (PVG-H5257) is expressed from human 293 cells (HEK293). It contains AA Thr 41 - Asp 171 (Accession # Q6DKI7-1).

 

Molecule : PVRIG

 

Synonyms : C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_076975.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 40.1 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. As a result of glycosylation, the protein migrates as 50 kDa under reducing (R) condition, and 90 kDa under non-reducing (NR) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

 

References :

(1) Xu F., et.al. 2017, Cancer Immunol Immunother., 66(10), 1367-1375.
(2) Zhu, Y., et.al. 2016, J. Exp. Med., 213,167-76.