Human PTPRD Protein, His Tag

Source : 

Human PTPRD, His Tag (PTD-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Glu 1265 (Accession # P23468-1).

 

Molecule : PTPRD

 

Synonyms : PTPRD,R-PTP-delta

 

Format : Powder

 

Category : Enzymes

 

Accession : NP_002830.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 140.0 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 140.0 kDa. The protein migrates as 19 kDa and 120-130 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Receptor-type tyrosine-protein phosphatase delta is an enzyme that is encoded by the PTPRD gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRD has been shown to interact with PTPRS and liprin-alpha-1. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. Mutations in the PTPRD gene are associated with autism, obsessive–compulsive disorder, and breast cancer.

 

References :

(1)Pulido R., etal., 1995, J Biol Chem., 270 (12): 6722-6728.
(2)Mizuno K., et al., 1993, Mol. Cell Biol., 13 (9): 5513-5523.
(3)Wallace MJ., et al., 1998, Mol. Cell Biol., 18 (5): 2608-2616.