Human PTH1R / PTHR1 Protein, His Tag

Source : 

Human PTH1R, His Tag (PTR-H5222) is expressed from human 293 cells (HEK293). It contains AA Asp 27 - Gly 188 (Accession # Q03431-1).

 

Molecule : PTH1R

 

Synonyms : PTH1R,PTHR,PTHR1

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_000307.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 19.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.6 kDa. The protein migrates as 27-43 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Parathyroid hormone/parathyroid hormone-related peptide receptor is also known as Parathyroid hormone 1 receptor (PTH1R), PTHR1, PTH/PTHrP type I receptor (PTH/PTHr receptor), which belongs to the G-protein coupled receptor 2 family. PTH1R / PTHR1 is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

 

References :

(1) Johnston C.A., et al., 2008, Structure 16:1086-1094.
(2) Pioszak A.A., et al., 2010, J. Biol. Chem. 285:12435-12444.