Human PSCA Protein, His Tag

Source : 

Human PSCA, His Tag (PSA-H52H6) is expressed from human 293 cells (HEK293). It contains AA Leu 12 - Ser 86 (Accession # O43653-1).

 

Molecule : PSCA

 

Synonyms : PSCA,UNQ206,PRO232

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_005663.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 10.4 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 10.4 kDa. The protein migrates as 18-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored protein, plays an important role in tumorigenesis. The prostate stem cell antigen (PSCA) gene, which encodes a prostate-specific antigen (PSA), was identified as a gene involved in cell adhesion and proliferation. PSCA may be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

 

References :

(1) Sakamoto H, et al. 2008. Nat Genet. 40(6):730-40.
(2) Jensen MM, et al. 2015. Neurobiol Aging. 36(4):1629-1638.
(3) Li E, et al. 2017. Prostate. 77(16):1563-1572.