Human Prolactin R / PRLR Protein, His Tag

Source : 

Human Prolactin R, His Tag (PRR-H52Ha) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).

 

Molecule : Prolactin R

 

Synonyms : Prolactin R,PRLR,PRL-R

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : NP_000940.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 26.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 150 mM NaCl, pH7.5

 

Description :

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

 

References :

(1) Pujianto DA., et al., 2010, Endocrinology. 151(3):1269-79. (2) Trott JF., et al.,2003, J Mol Endocrinol, 30(1):31-47. (3) Goffin V., et al., 2017, Pharmacol Ther. 179:111-126.