Human PROCR / EPCR / CD201 Protein, Fc Tag

Source : 

Human PROCR, Fc Tag (PRR-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Thr 209 (Accession # AAH14451).

 

Molecule : PROCR

 

Synonyms : PROCR,EPCR,CD201,APC receptor,CCCA,CCD41

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : AAH14451

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 48.6 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.6 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.

 

References :

(1) Fukudome K., et al., 1994, J. Biol. Chem. 269:26486-26491.
(2) Oganesyan V., et al., 2002, J. Biol. Chem. 277:24851-24854.