Human PLAU / uPA Protein, His Tag
Proteins and Peptides
- 貨號 Cat. No.
- PLU-H5229
- 規格 Size
- 50ug
- 品牌 Brand
- ACROBiosystems
- Species
- Human
- Conjugate
- Unconjugated
- Expression System
- HEK293
- Tag
- His Tag
Description
Source :
Human PLAU, His Tag (PLU-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Leu 431 (Accession # NP_002649.1).
Molecule : PLAU
Synonyms : Urokinase,PLAU,ATF,UPA,URK,u-PA,BDPLT5,QPD
Format : Powder
Category : Enzymes
Accession : NP_002649.1
Storage : -20℃
Shipping condition : Powder,RT
Molecular Weight : 47.2 kDa
Characteristics :
Human PLAU, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 47.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Please note that the protein is not a
Endotoxin Level : Less than 1.0 EU per μg by the LAL method.
Buffer : 50 mM Sodium Acetate, 100 mM NaCl, pH5.0
Description :
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
References :
(1) Nagai M., et al., 1985, Gene 36:183.
(2) Jacobs P., et al., 1985, DNA 4:139.
(3) Harbeck, N. et al., 2002, Clin. Breast Cancer 3:196.
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